GENERAL CATALOGUE
NL13
HY-162895 · 50 mg
MedChemExpress · Cat: HY-162895
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medchemexpress.com/nl13.html
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Catalog No: HY-162895
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
NL13 is a Polo-like kinase 4 PLK4 inhibitor with an IC50 value of 2.32 ?M. NL13 can inhibit the viability of PC3 and DU145 prostate cancer cells, with IC50 values of 3.51 ?M and 2.53 ?M, respectively. NL13 can lead to the inactivation of the AKT signaling pathway by downregulating CCNB1/CDK1, inducing G2/M cell cycle arrest, and triggering apoptosis through the cleavage of caspase-9/caspase-3. In prostate cancer mice, NL13 can inhibit tumor growth.
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