GENERAL CATALOGUE
NLRP3/AIM2-IN-3
HY-144226 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-144226
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medchemexpress.com/nlrp3-aim2-in-3.html
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Catalog No: HY-144226
CAS No: 1787787-60-3
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
NLRP3/AIM2-IN-3 compound 59 is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 AAasAasAA+/- 0.008 ?M. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization.
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