NLRP3-IN-81

Description

NLRP3-IN-81 N102 is a BBB-penetrable inhibitor against NLRP3 inflammasome-dependent pyroptosis with an EC50 of 0.029 ?M against cell pyroptosis induced by Nigericin HY-127019 . NLRP3-IN-81 potently inhibits NLRP3-dependent activation of caspase-1 and the release of IL-1?. NLRP3-IN-81 disturbs the interaction of NLRP3 with the adaptor protein ASC and inhibits ASC oligomerization. NLRP3-IN-81 can be used for pyroptosis-related diseases research, such as inflammatory bowel diseases and type 2 diabetes.