GENERAL CATALOGUE
Nolatrexed dihydrochloride
HY-108474 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-108474
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medchemexpress.com/Nolatrexed_dihydrochloride.htmlCatalog No: HY-108474
CAS No: 152946-68-4
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Nolatrexed dihydrochloride AG 337 is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer.
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