Norquetiapine

Description

Norquetiapine N-Desalkylauetiapine , a metabolite of Quetiapine HY-14544 , is a selective HCN1 channel inhibitor, with an IC50 of 13.9 ?M. Norquetiapine selectively inhibits noradrenaline reuptake, is a partial 5-HT1A Ki = 45 nM receptor agonist, and acts as an antagonist at presynaptic?2 Ki = 237 nM , 5-HT2C Ki = 107 nM , and 5-HT7 Ki = 76 nM receptors. Norquetiapine blocks the human cardiac sodium channel Nav1.5 in a state-dependent manner. Norquetiapine shows partial anti-inflammatory effects in LPS HY-D1056 injected C57BL/6 mice. Norquetiapine can be used for the study of depression and inflammation.