

Z05701 · 100 ug
GenScript · Cat: Z05701
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genscript.com/protein/Z05701-Notch_1_His_Avi_Human.htmlDescription
Human Notch-1 is a 300 kDa type I transmembrane glycoprotein that is one of four human Notch homologues involved in developmental processes.Notch-1 functions as a receptor for membrane-bound ligands Jagged-1 JAG1 , Jagged-2 JAG2 and Delta-1 DLL1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain NICD it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
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