GENERAL CATALOGUE
NP10679
HY-148825 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-148825
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medchemexpress.com/np10679.htmlCatalog No: HY-148825
Category: GPCR G Protein
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
NP10679 is a selective, pH dependent GluN2B subunit-specific N-methyl-D-aspartate NMDA receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC50s of 23 and 142 nM at pH 6.9 and 7.6, respectively. NP10679 is a histamine H1 antagonist and a hERG channel inhibitor with IC50s of 73 and 620 nM, respectively. NP10679 is a reversible inhibitor of human liver CYP enzymes.
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