GENERAL CATALOGUE
NP3-146 sodium
HY-145087A · 5 mg
MedChemExpress · Cat: HY-145087A
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Catalog No: HY-145087A
CAS No: 1995068-96-6
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
NP3-146 sodium is a NLRP3 inflammasome inhibitor through locking the NACHT domain of NLRP3. NP3-146 sodium shows potent inhibitory activity against IL-1? release with an IC50 value of 0.171 ?M in LPS HY-D1056 /Nigericin HY-127019 -stimulated BMDM cells. NP3-146 sodium regulates the levels of cleaved Caspase-1 and cleaved IL-1? in cell supernatants. NP3-146 sodium can be used for the research of inflammatory diseases.
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