GENERAL CATALOGUE
NPD-001
HY-136637 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-136637
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Catalog No: HY-136637
CAS No: 469863-16-9
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
NPD-001 is a potent Trypanosoma brucei phosphodiesterases 1/2 TbrPDEB1/2 inhibitor, with IC50 values of 4 and 3 nM, respectively. NPD-001 also inhibits hPDE4. NPD-001 can increase cAMP levels in parasites, prevent cytokinesis, and cause the parasites to form multinucleated, multi-flagellated cells that eventually lyse. NPD-001 can be used for the research of infection.
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