GENERAL CATALOGUE
NPD-2975
HY-155732 · 1 mg
MedChemExpress · Cat: HY-155732
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medchemexpress.com/npd-2975.htmlCatalog No: HY-155732
CAS No: 3032452-65-3
Category: Anti-infection
Pack Size: 1 mg
Brand: MedChemExpress
Description
NPD-2975 compound 30 is an orally active antitrypanosomal agent, against Human African Trypanosomiasis HAT . NPD-2975 has low toxicity potential against human MRC-5 lung fibroblasts, and acute mouse model of T. b. brucei infection. NPD-2975 shows acceptable metabolic stability, inhibits T. b. brucei with IC500 of 70 nM in vitro. NPD-2975 also inhibits CYP enzymes resulted in IC50 values of 0.16 and 0.42 ?M against CYP1A2 and CYP2C19, respectively.
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