[Nphe1]Nociceptin(1-13)NH2

Description

Nphe1 Nociceptin 1-13 NH2, a novel nociceptin/orphanin FQ NC endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. Nphe1 nociceptin 1-13 NH2 binds selectively to recombinant nociceptin receptors pKi=8.4 and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells pA2=6.0 . Nphe1 Nociceptin 1-13 NH2 has the potential to act as an analgesic agent.