NR2F2-IN-1

Description

NR2F6 modulator-2 CIA1 is a potent and selective orphan nuclear receptor COUP-TFII NR2F2 inhibitor. NR2F6 modulator-2 substantially inhibits COUP-TFIIAAasAasAadriven NGFIA reporter expression. NR2F6 modulator-2 directly binds to the COUP-TFII ligand-binding domain and disrupts COUP-TFII interaction with transcription regulators, including FOXA1, thus repressing COUP-TFII activity on target gene regulation.