NRCAM (13T10) Rabbit Monoclonal Antibody

Description

EnkiLife offers the NRCAM (13T10) Rabbit Monoclonal Antibody. This antibody reacts with Human species and is suitable for WB,IHC,IP application. Alternative Names of Immunogen: Bravo; hBravo; Neuronal cell adhesion molecule; Ng CAM related; NgCAM related cell adhesion molecule; Nr CAM; Nrcam; . The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:2000-1:20000,IHC 1:200-1:500,IP 1:20-1:50 Background: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier.