GENERAL CATALOGUE
Nrf2-IN-3
HY-149508 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-149508
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Catalog No: HY-149508
CAS No: 6325-13-9
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Nrf2-IN-3 Compound R16 is a small-molecule NRF2 inhibitor and increases reactive oxygen species ROS production. Nrf2-IN-3 selectively binds KEAP1 mutants and restores their NRF2-inhibitory function by repairing the disrupted KEAP1/NRF2 interactions, leading to proteasome-dependent NRF2 degradation in cells. Nrf2-IN-3 sensitizes KEAP1-mutated tumor cells to Cisplatin HY-17394 , Gefitinib HY-50895 , and KEAP1 G333C-mutated xenograft to Cisplatin .
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