GENERAL CATALOGUE
NSC 194308
HY-153736 · 5 mg
MedChemExpress · Cat: HY-153736
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medchemexpress.com/nsc-194308.htmlCatalog No: HY-153736
CAS No: 90379-42-3
Category: Cell Cycle DNA Damage
Pack Size: 5 mg
Brand: MedChemExpress
Description
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs RRM1 and RRM2 . NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations.
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