NSCLC-IN-1

Description

NSCLC-IN-1 Compound A10-2 induces mitophagy and ferroptosis through targeting transmembrane BAX inhibitor motif containing 6 TMBIM6 . NSCLC-IN-1 induces mitochondrial Ca2+ imbalance, leading to mitochondrial damage. NSCLC-IN-1 reduces intracellular glutathione GSH , increases the accumulation of lipid peroxides LPO and malondialdehyde MDA content. NSCLC-IN-1 is a potent anti-NSCLC agent.