GENERAL CATALOGUE
NVP-DKY709
HY-144998 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-144998
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medchemexpress.com/nvp-dky709.htmlCatalog No: HY-144998
CAS No: 2291360-73-9
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
NVP-DKY709 is an orally active and selective IKZF2 molecular glue degrader with the Dmax and DC50 of 53 % and 4 nM, respectively. In addition, NVP-DKY709 can degrade IKZF4 DC50: 13 nM and SALL4 DC50: 2 nM . NVP-DKY709 exerts anti-tumor activity by binding with CRBN to change conformation and recruit and degrade IKZF2.
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