GENERAL CATALOGUE
OICR41114
HY-169389 · 50 mg
MedChemExpress · Cat: HY-169389
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Manufacturer product page
medchemexpress.com/oicr41114.htmlCatalog No: HY-169389
Category: Epigenetics
Pack Size: 50 mg
Brand: MedChemExpress
Description
OICR41114 PROTAC 4 is a WDR5-targeting PROTAC degrader. OICR41114 degrades endogenous WDR5 with an EC50 and Dmax values of 40 nM and 49 %, respectively. OICR41114 degrades HiBiT-tagged WDR5 in a proteasome-dependent manner. OICR41114 is composed of target protein ligand red part Dimethyl-F-OICR-9429-COOH HY-141799 , E3 ligase ligand blue part OICR-8268-acrylic acid HY-169390 and PROTAC linker black part Amino-PEG9-amine HY-140210 . The conjugate of E3 ligase ligand and linker is OICR-8268-acrylic acid-amino-PEG9-amine HY-169391 .
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