Okadaic acid

Description

Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases PP . Okadaic acid has a significantly higher affinity for PP2A IC50=0.1-0.3 nM , and inhibits PP1 IC50=15-50 nM , PP3 IC50=3.7-4 nM , PP4 IC50=0.1 nM , PP5 IC50=3.5 nM , but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation.