Oleuropein Aglycone

Description

Oleuropein Aglycone 3,4-DHPEA-EA is a polyphenol and the aglycone form of oleuropein HY-N0292 , formed by enzymatic, acidic or acetylated hydrolysis of oleuropein. Dietary intake of oleuropein Aglycone 50 mg/kg diet increases the number of neuronal autophagic vesicles, reverses cognitive deficits in the TgCRND8 transgenic mouse model of Alzheimers disease, and reduces the levels of histone deacetylase 2 HDAC2 in the cortex and hippocampus. Oleuropein Aglycone increases urinary norepinephrine, interscapular brown adipose tissue epinephrine, and UCP1 protein levels, and reduced plasma leptin levels and total abdominal adipose tissue weight in a rat model of high-fat diet-induced obesity. Oleuropein Aglycone also reduced lung neutrophil infiltration, lipid peroxidation, and IL-1? levels in a mouse model of carrageenan-induced pleurisy.