GENERAL CATALOGUE
ONX-0914 TFA
HY-13207A · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-13207A
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medchemexpress.com/onx-0914-tfa.htmlCatalog No: HY-13207A
Category: Anti-infection
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
ONX-0914 PR-957 TFA is a selective inhibitor of low-molecular mass polypeptide-7 LMP7 , the chymotrypsin-like subunit of the immunoproteasome. ONX-0914 TFA blocks cytokine production and attenuates progression of experimental arthritis. ONX-0914 TFA is a noncompetitive irreversible inhibitor of the mycobacterial proteasome Ki=5.2 ?M . ONX-0914 TFA reactivates latent HIV-1 through p-TEFb activation mediated by HSF-1.
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