GENERAL CATALOGUE
Oritinib
HY-139920 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-139920
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Catalog No: HY-139920
CAS No: 2035089-28-0
Category: JAK STAT Signaling
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
Oritinib SH-1028 , an irreversible third-generation EGFR TKI, overcomes T790M-mediated resistance in non-small cell lung cancer. Oritinib SH-1028 , a mutant-selective inhibitor of EGFR kinase activity, inhibits EGFRWT, EGFRL858R, EGFRL861Q, EGFRL858R/T790M, EGFRd746-750 and EGFRd746-750/T790M kinases, with IC50s of 18, 0.7, 4, 0.1, 1.4 and 0.89 nM, respectively.
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