GENERAL CATALOGUE
ORM-5029
HY-164202 · 1 mg
MedChemExpress · Cat: HY-164202
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Catalog No: HY-164202
Category: Antibody-drug Conjugate ADC Related
Pack Size: 1 mg
Brand: MedChemExpress
Description
ORM-5029 is a first-in-class human epidermal growth factor receptor 2 HER2 -targeted antibody-drug conjugate ADC comprised of SMol006, a highly potent GSPT1 degrader, conjugated to Pertuzumab HY-P9912 . ORM-5029 exhibits robust efficacy across 14 HER2-positive breast cancer cell lines, with IC50 values ranging from 0.3 to 14.4 nM.ORM-5029 demonstrates anti-tumor activity in the BT474 xenograft model. ORM-5029 can be used for study of breast cancer.
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