GENERAL CATALOGUE
Os30
HY-155358 · 5 mg
MedChemExpress · Cat: HY-155358
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Catalog No: HY-155358
CAS No: 2998928-68-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
Os30, a potent fourth-generation EGFR inhibitor, is a potent EGFRC797S-TK inhibitor with IC50 values of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively. Os30 can suppress EGFR phosphorylation, arrest at G1 phase and induce the apoptosis of KC-0116 BaF3-EGFRDel19/T790M/C797S cells. Os30 shows potent antitumor efficacy on non-small cell lung cancer NSCLC with EGFmRC797S mutation.