GENERAL CATALOGUE
Osilodrostat
HY-16276 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-16276
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Catalog No: HY-16276
CAS No: 928134-65-0
Category: Metabolic Enzyme Protease
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
Osilodrostat LCI699 is a potent, orally active11?-hydroxylase CYP11B1 inhibitor with an IC50 value of 35 nM. Osilodrostat is a potent, orally aldosterone synthase CYP11B2 inhibitor with IC50 values of 0.7 nM and 160 nM for human aldosterone synthase and rat aldosterone synthase, respectively. Osilodrostat inhibits aldosterone and corticosterone synthesis. Osilodrostat has blood pressure lowering ability. Osilodrostat can be used for research of Cushing syndrome CS .