GENERAL CATALOGUE
Osunprotafib hydrochloride
HY-145923B · 50 mg
MedChemExpress · Cat: HY-145923B
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medchemexpress.com/osunprotafib-hydrochloride.htmlCatalog No: HY-145923B
CAS No: 2986745-48-4
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
Osunprotafib ABBV-CLS-484 hydrochloride is an orally active and selective active site PTPN1 IC50: 2.5?nM and PTPN2 IC50: 1.8?nM inhibitor. Osunprotafib hydrochloride has 6-8-fold weaker activity on PTPN9 and no detectable activity on SHP-1 or SHP-2. Osunprotafib hydrochloride increases the sensitivity of human cancer cell lines to IFN?. Osunprotafib hydrochloride generates robust anti-tumor immunity by enhancing JAK-STAT signalling and reducing T?cell dysfunction.
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