p-FOXO3A (S253) Antibody, mAb, Rabbit

Description

Transcriptional activator that recognizes and binds to the DNA sequence 5- AG TAAA TC A-3 and regulates different processes, such as apoptosis and autophag.Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins.Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3UTR of MYC transcript and prevent its translation PubMed:21329882 . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription PubMed:23283301 . In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation By similarity . Also acts as a key regulator of regulatory T-cells Treg differentiation by activating expression of FOXP3 PubMed:30513302 .