p-SMAD2 (S250) Antibody, mAb, Rabbit

Description

Receptor-regulated SMAD R-SMAD that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta transforming growth factor and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells By similarity .