GENERAL CATALOGUE
P53R3
HY-122578 · 10 mM * 1 mL in DMSO
MedChemExpress · Cat: HY-122578
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medchemexpress.com/p53r3.htmlCatalog No: HY-122578
CAS No: 922150-12-7
Category: Apoptosis
Pack Size: 10 mM * 1 mL in DMSO
Brand: MedChemExpress
Description
P53R3 is a potent p53 reactivator and restores sequence-specific DNA binding of p53 hot spot mutants, including p53R175H, p53R248W and p53R273H. P53R3 induces p53-dependent antiproliferative effects with much higher specificity than PRIMA-1. P53R3 enhances the recruitment of wild-type p53 and p53M237I to several target gene promoters. P53R3 strongly enhances the mRNA, total protein and cell surface expression of the death receptor death receptor 5 DR5 . P53R3 is used for cancer research.
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