PAD4-IN-3

Description

PAD4-IN-3 compound 4B is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan K-CRGDV , resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps NETs , and improve the tumor immune microenvironment in response to the tumor microenvironment.