Paeoniflorin-6?-O-benzene sulfonate

Description

Paeoniflorin-6?-O-benzene sulfonate CP-25 is the inhibitor for G protein-coupled receptor kinase 2 GRK2 that inhibits the translocation of GRK2 to the cell membrane, inhibits JAK1/STAT3 signaling pathway. Paeoniflorin-6?-O-benzene sulfonate inhibits IL-17A/CXCL2-induced proliferation of HaCaT. Paeoniflorin-6?-O-benzene sulfonate reduces the levels of inflammatory factors and chemokines such as IL-17A, IL-17F, IFN-?, TNF-?, IL-22, IL-23, CXCL2, CXCL3 and CXCL9, alleviates Imiquimod HY-B0180 -induced psoriasis in mouse model.