PAK4-IN-5

Description

PAK4-IN-5 Compound 12i is a PAK4 inhibitor IC50: 7.68 nM for PAK4, 1872.01 nM for PAK1 . PAK4-IN-5 binds to PAK4 stably via multiple interactions. PAK4-IN-5 inhibits the proliferation and the migratory potential of MDA-MB-231 cells by inhibiting the phosphorylation of PAK4 and LIMK1. PAK4-IN-5 arrests cell cycle in the G0/G1 phase, induces apoptosis and ROS production. LD50: >500 mg/kg for mice p.o. .