GENERAL CATALOGUE
Pamidronate disodium
HY-B0012A · 5 mg
MedChemExpress · Cat: HY-B0012A
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Catalog No: HY-B0012A
CAS No: 57248-88-1
Category: Immunology Inflammation
Pack Size: 5 mg
Brand: MedChemExpress
Description
Pamidronate disodium CGP 23339A , the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium can inhibit the signaling of Wnt and ?-catenin, and is applicable for research on osteoporosis and osteosarcoma.
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