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Pamidronate disodium pentahydrate
GENERAL CATALOGUE

Pamidronate disodium pentahydrate

HY-B0730 · 10 mM * 1 mL in Water

MedChemExpress · Cat: HY-B0730

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Catalog No: HY-B0730
CAS No: 109552-15-0
Category: Immunology Inflammation
Pack Size: 10 mM * 1 mL in Water
Brand: MedChemExpress

Description

Pamidronate disodium pentahydrate, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronate disodium pentahydrate significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronate disodium pentahydrate can inhibit the signaling of Wnt and ?-catenin, and is applicable for research on osteoporosis and osteosarcoma.

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