PAN endonuclease-IN-1

Description

PAN endonuclease-IN-1 Compound 23 is a potent PAN endonuclease inhibitor, with Kd values of 277 ?M, 384 ?M and 328 ?M for WT, I38T and E23K PAN endonucleases, respectively. The RNA-dependent RNA polymerase acidic N-terminal PAN endonuclease, a critical component of influenza viral replication machinery, is an antiviral target.