GENERAL CATALOGUE
pan-KRAS-IN-5
HY-163299 · 5 mg
MedChemExpress · Cat: HY-163299
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Catalog No: HY-163299
CAS No: 3027172-23-9
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
pan-KRAS-IN-5 is a pan-KRAS translation inhibitor by targeting 5?-UTR RNA G-quadruplexes rG4s . pan-KRAS-IN-5 strongly binds to and stabilizes KRAS rG4s, inhibits KRAS translation, and blocks the MAPK and PI3K-AKT pathways. pan-KRAS-IN-5 induces cell cycle arrest, prompts apoptosis in KRAS-driven cancer cells. pan-KRAS-IN-5 inhibits tumor growth and KRAS expression in KRAS-mutant xenograft. KRAS-IN-5 can be used for KRAS-driven cancer research.
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