GENERAL CATALOGUE
PARP/EZH2-IN-2
HY-161083 · 50 mg
MedChemExpress · Cat: HY-161083
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Manufacturer product page
medchemexpress.com/parp-ezh2-in-2.htmlCatalog No: HY-161083
Category: Cell Cycle DNA Damage
Pack Size: 50 mg
Brand: MedChemExpress
Description
PARP/EZH2-IN-2 compound 12e is a dual target PARP1 and EZH2 inhibitor, with IC50 values of 6.89 and 27.34 nM, respectively. PARP/EZH2-IN-2 shows anticancer activity, with no toxicity to normal cells. PARP/EZH2-IN-2 achieves synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induces cell death by regulating excessive autophagy.
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