GENERAL CATALOGUE
PARP1-IN-27
HY-161934 · 50 mg
MedChemExpress · Cat: HY-161934
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Catalog No: HY-161934
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
PARP1-IN-27 Compound 9B is the inhibitor for PARP1 and PARP2, with IC50 of 2.53 nM and 6.45 nM in cell SUM149PT. PARP1-IN-27 inhibits the proliferation of BRCA-mutated cancer cells SUM149PT, HCC1937 and Capan-1, with IC50 of 0.62, 1.91 and 4.26 ?M respectively. PARP1-IN-27 aggravates DNA double-strand breaks, increases ROS generation, arrests cell cycle at G2/M phase, and induces apoptosis in SUM149PT.
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