PARP1 PROTAC 180055

Description

PARP1 PROTAC 180055 Compound 180055 is a selective PARP1 PROTAC degrader DC50 in T47D and MDA-MB-231 cell lines is 180?nM and 240?nM, respectively . PARP1 PROTAC 180055 promotes ubiquitination and degradation of PARP1 as well as inhibits PARP1 enzyme activity without a noticeable DNA trapping effect. PARP1 PROTAC 180055 inhibits tumors carrying BRCA mutations with a minor impact on the growth of normal cells Pink: PARP1 ligand HY-10617A ; Blue: E3 ligase VHL ligand HY-125845 ; Black: linker HY-W014787 .