GENERAL CATALOGUE
PAWI-2
HY-123929 · 5 mg
MedChemExpress · Cat: HY-123929
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medchemexpress.com/pawi-2.htmlCatalog No: HY-123929
CAS No: 1448427-02-8
Category: Apoptosis
Pack Size: 5 mg
Brand: MedChemExpress
Description
PAWI-2 is a p53-Activator and Wnt Inhibitor. PAWI-2 inhibits ?3-KRAS signaling independent of KRAS. PAWI-2 selectively inhibits phosphorylation of TBK1. PAWI-2 activates apoptosis activation of caspase-3/7 , and induces PARP cleavage. PAWI-2 promotes optineurin translocation into the nucleus and causes G2/M arrest. PAWI-2 reverses cancer stemness and overcomes drug resistance in an integrin ?3 KRAS-dependent human pancreatic cancer stem cells hPCSCs . PAWI-2 inhibits growth of tumors from hPCSCs in orthopic xenograft mice model.
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