GENERAL CATALOGUE
PB28
HY-108511A · 50 mg
MedChemExpress · Cat: HY-108511A
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Catalog No: HY-108511A
CAS No: 172906-90-0
Category: Anti-infection
Pack Size: 50 mg
Brand: MedChemExpress
Description
PB28 is a cyclohexylpiperazine derivative and a high affinity and selective sigma 2 ?2 receptor agonist with a Ki of 0.68 nM. PB28 is also a ?1 antagonist with a Ki of 0.38 nM. PB28 is less affinity for other receptors. PB28 inhibits electrically evoked twitch in guinea pig bladder and ileum with EC50 values of 2.62 ?M and 3.96 ?M, respectively. PB28 can modulate SARS-CoV-2-human protein-protein interaction. PB28 induces caspase-independent apoptosis and has antitumor activity.
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