PBD dimer-4

Description

PBD dimer-4 Compound 7 is a C1-subsitituted PBD dimer. PBD dimer-4 has high DNA-binding affinity, DNA cross-linking ability and potent cytotoxicity against MDA-MB-231 cells IC50: 236 nM . PBD dimer-4 can be used as a payload of ADC Loncastuximab tesirine HY-P99349 to treat several different cancer types.