GENERAL CATALOGUE
PC-046
HY-120561 · 50 mg
MedChemExpress · Cat: HY-120561
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medchemexpress.com/pc-046.html
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Catalog No: HY-120561
CAS No: 1202401-59-9
Category: Apoptosis
Pack Size: 50 mg
Brand: MedChemExpress
Description
PC-046 is a multi-target inhibitor for tyrosine receptor kinase B TrkB , IRAK-4 and Pim-1, with IC50 of 13.4 ?M, 15.4 ?M and 19.1 ?M, respectively. PC-046 exhibits cytotoxicity against pancreatic cancer cell BxPC3 with IC50 of 7.5-130 nM. PC-046 induces apoptosis and arrests cell cycle at G2/M phase in BxPC3. PC-046 exhibits antitumor efficacy and exhibits good pharmacokinetic characteristics in mice.
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