GENERAL CATALOGUE
PCNA-I1
HY-124012 · Free Sample (0.1 - 0.2 mg)
MedChemExpress · Cat: HY-124012
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Manufacturer product page
medchemexpress.com/pcna-i1.htmlCatalog No: HY-124012
CAS No: 444930-42-1
Category: Apoptosis
Pack Size: Free Sample (0.1 - 0.2 mg)
Brand: MedChemExpress
Description
PCNA-I1 is a selective small molecule inhibitor targeting proliferating cell nuclear antigen PCNA with anticancer activity. PCNA-I1 can stabilize the PCNA trimer structure Kd=0.14-0.41?M , reduce its binding to chromatin, induce tumor cell cycle arrest, inhibit DNA replication and repair, and enhance the anti-tumor effect of DNA damaging agents. PCNA-I1 can be used in the study of targeted therapy for prostate cancer, lung cancer and other tumors.
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