GENERAL CATALOGUE
PCSK9-IN-30
HY-161940 · 5 mg
MedChemExpress · Cat: HY-161940
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medchemexpress.com/pcsk9-in-30.htmlCatalog No: HY-161940
Category: Metabolic Enzyme Protease
Pack Size: 5 mg
Brand: MedChemExpress
Description
PCSK9-IN-30 Compound 3f is a PCSK9 inhibitor. PCSK9-IN-30 interacts with a cryptic binding groove of PCSK9, inhibiting the binding of PCSK9 to the low-density lipoprotein receptor LDLR IC50 = 537 nM , restoring the uptake of low-density lipoprotein LDL by liver cells, and ultimately reducing plasma cholesterol levels. PCSK9-IN-30 exhibits good bioavailability in mice and can be used for research in the field of cardiovascular diseases.