GENERAL CATALOGUE
PD-089828
HY-112345 · 5 mg
MedChemExpress · Cat: HY-112345
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medchemexpress.com/pd-089828.htmlCatalog No: HY-112345
CAS No: 179343-17-0
Category: JAK STAT Signaling
Pack Size: 5 mg
Brand: MedChemExpress
Description
PD-089828 is an ATP competitive inhibitor of FGFR-1, PDGFR-? and EGFR IC50s=0.15, 1.76, and 5.47 AAasAasAAmuM, respectively and a noncompetitive inhibitor of c-Src tyrosine kinase IC50=0.18 AAasAasAAmuM . PD-089828 also inhibits MAPK with an IC50 of 7.1 AAasAasAAmuM. PD-089828 inhibits PDGF-, EGF- and bFGF-mediated tyrosine kinase receptor autophosphorylation in vitro. PD-089828 has a long-lasting cellular activity.
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