GENERAL CATALOGUE
PD-156707
HY-123744 · 5 mg
MedChemExpress · Cat: HY-123744
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Catalog No: HY-123744
CAS No: 162412-70-6
Category: GPCR G Protein
Pack Size: 5 mg
Brand: MedChemExpress
Description
PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human ET-A and ET-B receptors with Ki values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure.
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