PDE?/NAMPT IN-1

Description

PDE?/NAMPT IN-1 Compound 17d is a dual inhibitor targeting phosphodiesterase 6 PDE6 KD=0.410 nM and nicotinamide phosphoribosyl transferase NAMPT IC50=2.21 nM . PDE?/NAMPT IN-1 blocks KRAS-related signal transduction and interferes with the synthesis of nicotinamide adenine dinucleotide NAD+ , inducing apoptosis in KRAS mutant pancreatic cancer cells. PDE?/NAMPT IN-1 is promising for research of KRAS mutant pancreatic cancer.