GENERAL CATALOGUE
PDHK1-IN-1
HY-170838 · 50 mg
MedChemExpress · Cat: HY-170838
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medchemexpress.com/pdhk1-in-1.htmlCatalog No: HY-170838
Category: Metabolic Enzyme Protease
Pack Size: 50 mg
Brand: MedChemExpress
Description
PDHK1-IN-1 compound 17 is a selective inhibitor of PDHK1 IC50=1.5 ?M with anticancer activity. PDHK1 negatively regulates the pyruvate dehydrogenase complex PDC , limiting the tricarboxylic acid TCA cycle and oxidative phosphorylation. Overexpression of PDHK1 can shift the metabolism towards an increased glycolysis dependence Warburg effect . PDHK1-IN-1 can inhibit the phosphorylation of the PDC E1? Ser232 recognition site of PDHK1 and the phosphorylation of Ser293.