PDK1 Rabbit Polyclonal Antibody

Description

EnkiLife offers the PDK1 Rabbit Polyclonal Antibody. This antibody reacts with Human,Mouse,Rat species and is suitable for WB,IHC,ICC/IF,ELISA application. Alternative Names of Immunogen: PDPK1; PDK1; 3-phosphoinositide-dependent protein kinase 1; hPDK1. The product boasts remarkable high specificity, outstanding reproducibility, and exceptional affinity, making it a reliable and superior choice for your needs. Dilution Ratio: WB 1:500-1:2000,IHC 1:100-1:300,ICC/IF 1:50-1:200,ELISA 1:5000-1:20000 Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein. function:Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. PTM:Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. similarity:Belongs to the protein kinase superfamily. similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. similarity:Contains 1 PH domain. similarity:Contains 1 protein kinase domain. subcellular location:Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. subunit:Interacts with TUSC4. tissue specificity:Appears to be expressed ubiquitously. Research Area:PPAR;mTOR;Focal adhesion;Insulin_Receptor;Aldosterone-regulated sodium reabsorption;Endometrial cancer;Prostate cancer;Non-small cell lung cancer;